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  • Title: Characteristics of Epstein-Barr virus-carrying lymphoblastoid cells derived from human tonsil: EBV production and autoantibody response.
    Author: Takimoto T, Tanaka S, Ishikawa S, Masuda K, Umeda R.
    Journal: ORL J Otorhinolaryngol Relat Spec; 1989; 51(5):257-61. PubMed ID: 2554232.
    Abstract:
    Tonsillar and peripheral blood lymphocytes from 20 patients with tonsillitis were examined for production of Epstein-Barr virus (EBV) and antinuclear antibodies within 2 weeks after EBV transformation. All established lymphoblastoid cell lines (LCLs) contained more than 90% EBV nuclear antigen-positive cells. However, no LCLs produced biologically active virus. On the other hand, 10 (50%) out of 20 tonsillar LCLs and 4 (20%) out of 20 peripheral blood LCLs produced autoantibodies. These results showed that there are differences in an EBV-induced lymphocyte autoantibody response between tonsillar lymphocytes and peripheral blood lymphocytes.
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