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  • Title: A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene.
    Author: Tsuchie H, Chang CH, Yoshida M, Vogt PK.
    Journal: Oncogene; 1989 Nov; 4(11):1281-4. PubMed ID: 2554234.
    Abstract:
    Avian sarcoma virus 1 (ASV-1) was isolated from a spontaneous sarcoma of an adult chicken. It is a replication-defective virus that induces fibrosarcomas in young chickens and oncogenic transformation in cultured chick embryo fibroblasts. The ASV-1 genome has been cloned in the lambda gt WES.lambda B vector from closed circular viral DNA extracted from infected cells. The nucleotide sequence of the oncogene insert in the ASV-1 genome has been determined. It is virtually identical to the sequence of the oncogene crk recently discovered in the avian sarcoma virus CT10. ASV-1 and CT10 are two independent retrovirus isolates carrying the crk oncogene.
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