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  • Title: Decreased phosphofructokinase activity during the development of triorthocresyl-phosphate-induced delayed neuropathy.
    Author: Hernandez AF, Pla A, Villanueva E.
    Journal: Toxicol Lett; 1989 Oct; 49(1):35-40. PubMed ID: 2554537.
    Abstract:
    The effect of triorthocresyl phosphate on selected glycolytic enzymes (hexokinase, phosphofructokinase, glyceraldehyde 3-phosphate dehydrogenase, lactate dehydrogenase) was investigated during the development of organophosphate-induced delayed neuropathy. Only phosphofructokinase activity was decreased 15 days after treatment. The effect was dose-dependent and was observed in sciatic nerve while the brain enzyme activity was not affected.
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