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  • Title: Asymmetric intermolecular cobalt-catalyzed Pauson-Khand reaction using a P-stereogenic bis-phosphane.
    Author: Orgué S, León T, Riera A, Verdaguer X.
    Journal: Org Lett; 2015 Jan 16; 17(2):250-3. PubMed ID: 25545421.
    Abstract:
    The asymmetric intermolecular and catalytic Pauson-Khand reaction has remained an elusive goal since Khand and Pauson discovered this transformation. Using a novel family of P-stereogenic phosphanes, we developed the first catalytic system with useful levels of enantioselection for the reaction of norbornadiene and trimethylsilylacetylene. The results demonstrate that Co-bisphosphane systems are sufficiently reactive and that they lead to high selectivity in the intermolecular process.
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