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  • Title: [Lipid peroxidation and ATPase activity in synaptosomal and mitochondrial fractions of the brain in hypoxia].
    Author: Dzhafarov AI, Magomedov NM, Babaev KhF, Akhmedova GSh, Bekhbudova ZA.
    Journal: Vopr Med Khim; 1989; 35(4):51-6. PubMed ID: 2554591.
    Abstract:
    Acute hypoxia was accompanied by intensification of lipid peroxidation in synaptosomal and mitochondrial rat brain fractions as well as by inhibition of Na+, K+- and Mg2+-ATPases. Preadministration of antioxidants vitamin E and ionol into animals prevented distinctly the increase in lipid peroxidation rate, while the ATPases activity was unaltered. Inhibition of the ATPases may be considered as a result of impairing effect of the lipid peroxidation products, which appears to be of importance for structure-functional deteriorations of the nervous system in hypoxia.
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