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  • Title: Synaptosomal (Ca2+-Mg2+)-ATPASE activity modulation by cyclic AMP.
    Author: Rodriguez R, Toledo A, Sabrià J, Rodriguez J, Blanco I.
    Journal: Biochem Pharmacol; 1989 Oct 01; 38(19):3219-22. PubMed ID: 2554918.
    Abstract:
    Dibutyryl cyclic AMP, in a concentration-dependent manner, increased synaptosomal (Ca2+-Mg2+)-ATPase activity, but in synaptic plasma membranes lacked any effect. The maximal enzyme activity in synaptosomes was increased by 38%, leaving unaltered the extrasynaptosomal Ca2+ concentration necessary to reach it. In the presence of 5 microM cyclic AMP, cyclic AMP-dependent protein kinase increased (30%) maximal (Ca2+-Mg2+)-ATPase activity in synaptic plasma membranes, but the apparent affinity for Ca2+ was not modified. This effect was partially inhibited (60%) by a cyclic AMP-dependent protein kinase inhibitor. The data suggest that synaptosomal (Ca2+-Mg2+)-ATPase activity is modulated by a cyclic AMP-dependent phosphorylation reaction.
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