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  • Title: The effect of endothelin on noradrenergic transmission in rat and guinea-pig atria.
    Author: Reid JJ, Wong-Dusting HK, Rand MJ.
    Journal: Eur J Pharmacol; 1989 Sep 01; 168(1):93-6. PubMed ID: 2555203.
    Abstract:
    Pre-and postjunctional effects of 10 nM endothelin have been studied in rat and guinea-pig spontaneously beating isolated atria. Endothelin increased the rate and force of contraction of atria from both species, but decreased the positive inotropic and chronotropic responses to stimulation of intramural sympathetic nerves by approximately 60% in rat and by 10-15% in guinea-pig atria. The stimulation-induced release of noradrenaline from either rat or guinea-pig atria was not significantly changed by endothelin.
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