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  • Title: Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs.
    Author: Watanabe N, Vande Woude GF, Ikawa Y, Sagata N.
    Journal: Nature; 1989 Nov 30; 342(6249):505-11. PubMed ID: 2555717.
    Abstract:
    The Xenopus c-mos proto-oncogene product, pp39mos, accumulates in the unfertilized egg during maturation, is hyperphosphorylated and exhibits protein kinase activity. On fertilization, or soon after the completion of meiosis, the accumulated pp39mos undergoes selective proteolysis. Using an in vitro protease assay system, we show here that this specific proteolysis is caused by the calcium-dependent cysteine protease, calpain.
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