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  • Title: Characteristics of the cellular response of the rat conjunctiva to topically applied leukotriene B4.
    Author: Trocmé SD, Gilbert CM, Allansmith MR, Bloch KJ, Abelson MB.
    Journal: Ophthalmic Res; 1989; 21(4):297-302. PubMed ID: 2555760.
    Abstract:
    Cellular events in the rat conjunctiva were studied at 1, 6 and 24 h following the topical application of leukotriene B4. A significant increase was noted in the number of eosinophils (p less than 0.01) and neutrophils (p less than 0.05) at 1 h and only in eosinophils at 6 h after leukotriene B4 application at the 2-micrograms dose. At the 200-ng dose, the eosinophil count was significantly elevated at 1 h only, and the number of neutrophils was not significantly changed at any time point. No significant increase in cell counts was observed at the 20-ng dose. In conclusion, certain doses of topically applied leukotriene B4 significantly increased the number of eosinophils and neutrophils in the rat conjunctiva.
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