These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Total synthesis of (-)-lundurine A and determination of its absolute configuration.
    Author: Jin S, Gong J, Qin Y.
    Journal: Angew Chem Int Ed Engl; 2015 Feb 09; 54(7):2228-31. PubMed ID: 25557974.
    Abstract:
    A 15-step total synthesis of (-)-lundurine A (1) from easily accessible (S)-pyrrolidinone 18 is reported. A Simmons-Smith reaction allows the efficient, simultaneous assembly of the cyclopropyl C ring, the six-membered D ring, the seven-membered E ring, and the quaternary carbon stereocenters at C2 and C7. The absolute configuration of natural (-)-lundurine A was deduced to be 2R,7R,20R based on the stepwise construction of the stereocenters during the total synthesis.
    [Abstract] [Full Text] [Related] [New Search]