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  • Title: The endocrinopathy of POEMS syndrome.
    Author: Stewart PM, McIntyre MA, Edwards CR.
    Journal: Scott Med J; 1989 Oct; 34(5):520-2. PubMed ID: 2555917.
    Abstract:
    We describe the clinical features and post mortem findings in a patient with POEMS syndrome (P--polyneuropathy, O--organomegaly, E--endocrinopathy, M--M protein, S--skin changes), with particular emphasis on the evolution of the endocrinopathy over a three year period. In addition to gynaecomastia this case exhibited primary hypothyroidism and primary and secondary adrenal and gonadal failure. The widespread nature of the endocrine changes suggests that a circulating substance interferes with the action of trophic hormones, possibly by inhibiting second messenger production.
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