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  • Title: [Na,K-ATPase activity in the myocardial sarcolemma in ischemia].
    Author: Kim EA, Danilenko MP, Murzakhmetova MK, Vashchenko VI, Esyrev OV.
    Journal: Ukr Biokhim Zh (1978); 1989; 61(4):60-5. PubMed ID: 2555947.
    Abstract:
    The total time-controlled ischemia (up to 45 min) was studied for its effect on the Na,K-ATPase activity, content of nonesterified fatty acids (NEFA) and intensity of lipid peroxidation (LP) in sarcolemmal (SL) preparations and soluble fractions (SF) from the rat and guinea-pig left ventricles. A strong correlation between Na, K-ATPase inhibition and NEFA accumulation was revealed in the SF. On the contrary, changes in the NEFA content and LP level both in SL and SF did not correlate with a decrease in the enzymic activity. Pretreatment with albumin (0.5 mg/ml) induced equally small increase both in the control and in the ischemic SL preparations. It is suggested that the Na,K-ATPase activity during a short period of myocardial ischemia (up to 45 min) may be due to the NEFA accumulation in the cytosolic and/or extracellular space, but not in SL.
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