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  • Title: Lack of association between human herpesvirus and vestibular schwannoma: analysis of 121 cases.
    Author: Bhimrao SK, Maguire J, Garnis C, Tang P, Lea J, Akagami R, Westerberg BD.
    Journal: Otolaryngol Head Neck Surg; 2015 Mar; 152(3):513-7. PubMed ID: 25560404.
    Abstract:
    OBJECTIVE: To assess for the presence of human herpesvirus (HHV) using immunohistochemical and polymerase chain reaction (PCR) assay in surgically excised vestibular schwannoma (VS) samples. STUDY DESIGN: Cross-sectional study. SETTING: A retrospective laboratory-based study of tumors from patients with vestibular schwannoma. SUBJECTS AND METHODS: Tissue microarrays (TMAs) representing sporadic and NF2-associated VS from 121 patients, as well as appropriate positive and negative controls, were studied. TMA sections were immunostained using antibodies directed against HHV-1, HHV-2, HHV-3, HHV-4, HHV-5, and HHV-8. PCR was used for the detection of all 8 known human herpesviruses. RESULTS: There was no detectable HHV (HHV-1, HHV-2, HHV-3, HHV-4, HHV-5, HHV-8) by immunohistochemistry in any of the 121 cases of sporadic and NF2 cases analyzed. These data were further validated by DNA sequence analyses using PCR in a subset of the VS samples, all of which were found to be negative for all HHV. CONCLUSIONS: The data offer no support for an association between HHV and the development of sporadic or NF2-associated VS in humans.
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