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  • Title: Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum.
    Author: Souza SD, Franca CS, Niculau ES, Costa LC, Pinto JE, Alves PB, Marçal RM.
    Journal: Nat Prod Res; 2015; 29(22):2125-8. PubMed ID: 25560465.
    Abstract:
    Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K(+) concentrations (25 and 60 mM, respectively). OS shifted the concentration-response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol.
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