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  • Title: Sodium transport defect of ouabain-resistant renal Na,K-ATPase.
    Author: Anner BM, Imesch E, Moosmayer M.
    Journal: Biochem Biophys Res Commun; 1989 Nov 30; 165(1):360-7. PubMed ID: 2556141.
    Abstract:
    The murine renal Na,K-ATPase is resistant to cardiac glycosides. It is not yet known however whether altered active transport is associated with the drug-resistance. To investigate this problem Na,K-ATPases were purified from the outer medulla of both rat and rabbit kidneys and reconstituted identically into liposomes. The Na-stimulation of the Na,K-ATPase activity before reconstitution and of the Na-transport after reconstitution was measured. A Na-defect inherent in the ouabain-resistant rat Na,K-ATPase was discovered indicating a link between the cardiac glycoside sensitivity and the Na-transport.
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