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  • Title: Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism.
    Author: Schettini G, Landolfi E, Grimaldi M, Meucci O, Postiglione A, Florio T, Ventra C.
    Journal: Biochem Biophys Res Commun; 1989 Nov 30; 165(1):496-505. PubMed ID: 2556147.
    Abstract:
    The effect of interleukin 1 beta on prolactin secretion and on phosphoinositide turnover in anterior pituitary cells was evaluated. Interleukin 1 beta significantly inhibited TRH-stimulated prolactin secretion assessed by the reverse hemolytic plaque assay. In particular, the cytokine reduced the percentage of plaque forming cells, the plaque mean area, the large plaques percentage. TRH-stimulated inositol phosphate production was also significantly inhibited by interleukin 1 beta. This study shows that interleukin 1 beta reduces TRH-induced prolactin secretion through a direct action on pituitary cell, and attenuates the TRH-stimulated phosphoinositide breakdown. This latter effect may suggest that the reduced lactotropes sensitivity to TRH action may be partially due to interleukin 1 beta inhibition of phosphatidylinositol breakdown.
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