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  • Title: Gangliosides attenuate NMDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons.
    Author: Nicoletti F, Cavallaro S, Bruno V, Virgili M, Catania MV, Contestabile A, Canonico PL.
    Journal: Neuropharmacology; 1989 Nov; 28(11):1283-6. PubMed ID: 2556658.
    Abstract:
    Release of both D-[3H]aspartate and endogenous amino acids was measured in primary cultures of cerebellar granule cells. Two hour-pretreatment with the glycosphingolipids, GM1 or GT1b, attenuated the stimulation of excitatory amino acid release induced by depolarizing concentrations of K+ (50 mM). Gangliosides inhibited the phencyclidine (PCP)-sensitive component of depolarization-induced release, i.e. the amplification of release that follows activation of NMDA receptors by the endogenous glutamate.
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