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  • Title: Drug eruptions induced by allopurinol associated with HLA-B*5801.
    Author: Zeng M, Zhang M, Liu F, Yan W, Kong Q, Sang H.
    Journal: Indian J Dermatol Venereol Leprol; 2015; 81(1):43-5. PubMed ID: 25566896.
    Abstract:
    Allopurinol, a drug commonly used for treating gout and hyperuricemia, is a frequent cause of drug eruptions. Recent investigations suggest that HLA-BFNx015801 allele is a very strong marker for allopurinol-induced cutaneous adverse drug reactions (cADRs). In this article we report two cases of allopurinol-induced drug eruptions in patients carrying the HLA-BFNx015801 allele and review the literature on the association between HLA-BFNx015801 and allopurinol-induced cADRs based on a MEDLINE and PubMed search.
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