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  • Title: Simulation of short-term pressure regulation during the tilt test in a coupled 3D-0D closed-loop model of the circulation.
    Author: Lau KD, Figueroa CA.
    Journal: Biomech Model Mechanobiol; 2015 Aug; 14(4):915-29. PubMed ID: 25567754.
    Abstract:
    Short-term fluctuations in arterial pressures arising from normal physiological function are buffered by a negative feedback system known as the arterial baroreflex. Initiated by altered biomechanical stretch in the vessel wall, the baroreflex coordinates a systemic response that alters heart rate, cardiac contractility and peripheral vessel vasoconstriction. In this work, a coupled 3D-0D formulation for the short-term pressure regulation of the systemic circulation is presented. Including the baroreflex feedback mechanisms, a patient-specific model of the large arteries is subjected to a simulated head up tilt test. Comparative simulations with and without baroreflex control highlight the critical role that the baroreflex has in regulating variations in pressures within the systemic circulation.
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