These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of diethyldithiocarbamate on gastric and duodenal mucosal blood flow and vascular permeability in rats.
    Author: Teramura S, Murakami M, Saita H, Yoo JK, Kusaka S, Matsuo K, Kita T, Miyake T.
    Journal: Scand J Gastroenterol Suppl; 1989; 162():108-11. PubMed ID: 2556783.
    Abstract:
    Diethyldithiocarbamate (DDC), an inhibitor of superoxide dismutase, produced ulceration in the proximal duodenum of rats, and erosions or ulcers in the stomach. DDC given s. c. at 1.5 g/kg increased duodenal and gastric vascular permeability, and reduced blood flow. The decrease in gastric blood flow caused by DDC was attenuated by pretreatment with superoxide dismutase, and significantly inhibited by a xanthine oxidase inhibitor, allopurinol. It is suggested that the superoxide and other radicals damage the mucosal vasculature, and play a role in the pathogenesis of gastric and duodenal mucosal lesions.
    [Abstract] [Full Text] [Related] [New Search]