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  • Title: Noninvasive determination of absorption and reduced scattering coefficients of adult heads by time-resolved reflectance measurements for functional near infra-red spectroscopy.
    Author: Tanifuji T, Wang L.
    Journal: Annu Int Conf IEEE Eng Med Biol Soc; 2014; 2014():2849-52. PubMed ID: 25570585.
    Abstract:
    Absorption and reduced scattering coefficients (μ(a) and μ'(s)) of adult heads have been noninvasively determined by time-resolved reflectance measurements. The finite difference time domain (FDTD) analysis was used to calculate time-resolved reflectance from realistic adult head models with brain grooves containing a non-scattering layer. In vivo time-resolved reflectances of human heads were measured by a system composed of a time-correlated single photon counter and a diode laser. By minimizing the objective functions that compare theoretical and experimental time resolved reflectances, μ(a) and μ'(s) of brain were determined. It became clear that time-resolved measurements have enough sensitivity to determine both μ(a) and μ'(s) for superficial tissues, gray matter and white matter, except μ(s) for white matter.
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