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  • Title: [Effects of ethanol on the concentration of neuropeptides, ACTH and corticosterone during immobilization stress].
    Author: Iukhananov RIu, Rozhanets VV, Maĭskiĭ AI.
    Journal: Biull Eksp Biol Med; 1989 Oct; 108(10):455-7. PubMed ID: 2557102.
    Abstract:
    It was shown, that stress increased the level of ACTH, beta-endorphin and corticosterone in the blood plasma of the rat. Injection of ethanol (1 g/kg) decreased the level of ACTH, but increased the levels of beta-endorphin in the rat subjected to immobilization stress. The immobilization lowered the levels of met-enkephalin in the striatum and medulla oblongata, but increased the content of neuropeptide in the adrenal glands. The concentration of leu-enkephalin and DSIP remained unchanged following the stress. Ethanol reversed the action of immobilization on the level of met-enkephalin in the striatum, but increased the content of DSIP in the thalamus. These results indicate that ethanol modified the activity of pituitary-adrenal-axis during stress and probably the stress-protective action of ethanol partly performed with the involvement of DSIP.
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