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  • Title: Glycine reverses 7-chlorokynurenic acid-induced inhibition of [3H]MK-801 binding.
    Author: Sircar R, Frusciante MJ, Javitt DC, Zukin SR.
    Journal: Brain Res; 1989 Dec 18; 504(2):325-7. PubMed ID: 2557130.
    Abstract:
    7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding to the PCP receptor, and that this effect is reversed by addition of glycine. Since [3H]MK-801 binding is a measure of channel activation, our results are consistent with the hypotheses that 7-Cl KYNA exerts its NMDA receptor antagonism by acting at the glycine site, and that activation of the glycine site is required for NMDA channel activity to occur.
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