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  • Title: Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide.
    Author: Agrawal AG, Kumar A, Gide PS.
    Journal: Colloids Surf B Biointerfaces; 2015 Feb 01; 126():553-60. PubMed ID: 25576032.
    Abstract:
    The aim of this study was to develop self emulsifying drug delivery systems (SEDDS) of glipizide and to convert it into solid SEDDS (S-SEDDS) using Syloid(®) 244 FP as adsorbent. Solubility study, ternary phase diagram, robustness to dilution, thermodynamic stability study and globule size analysis were adopted to optimize liquid SEDDS. S-SEDDS were evaluated for various studies including in vivo study. The optimized liquid SEDDS formulation consisted of phosphatidylcholine, Tween 80 and Transcutol P as oil, surfactant and cosolvent. In vivo study demonstrated that blood glucose levels were efficiently controlled with S-SEDDS compared with pure drug. The results of this study suggest the potential use of developed S-SEDDS formulation for the delivery of poorly water-soluble drug glipizide.
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