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  • Title: [Adenomas of the liver and oral contraception. Clinical and therapeutic aspects apropos of a giant adenoma].
    Author: Dreyfus M, Jaeck D, Dreyfus J.
    Journal: Rev Fr Gynecol Obstet; 1989 Nov; 84(11):761-5. PubMed ID: 2557665.
    Abstract:
    The first cases of benign liver tumors following estroprogestative therapy were described in 1973. Since that time, this relation between cause and effect has been demonstrated. The authors report the case of a giant liver adenoma which developed after 13 years of uninterrupted use of oral contraceptives. The advantage of this disease is not so much its prevalence which is low, but its clinical diagnosis. In fact, failure to recognize this entity may result in dramatic complications such as haemorrhagic rupture of the liver. The therapeutic approaches, whether wait-and-see or aggressive, all present a common objective: permanent discontinuance of estroprogestative drugs.
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