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  • Title: Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.
    Author: Ni W, Li H, Wu A, Zhang P, Yang H, Yang X, Huang X, Jiang L.
    Journal: J Assist Reprod Genet; 2015 Mar; 32(3):369-74. PubMed ID: 25578539.
    Abstract:
    PURPOSE: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. METHODS: The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. RESULTS: We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. CONCLUSIONS: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.
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