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  • Title: Chondroitin sulphate-guided construction of polypyrrole nanoarchitectures.
    Author: Zhou Z, Zhu W, Liao J, Huang S, Chen J, He T, Tan G, Ning C.
    Journal: Mater Sci Eng C Mater Biol Appl; 2015 Mar; 48():172-8. PubMed ID: 25579911.
    Abstract:
    Nanospheres, nanocones, and nanowires are three typical polypyrrole (PPy) nanoarchitectures and electrochemically polymerized with the dope of chondroitin sulphate (CS) in this study. CS, a functional biomacromolecule, guides the formation of PPy nanoarchitectures as the dopant and morphology-directing agent. Combined with our previous reported other PPy nanoarchitectures (such as nanotube arrays and nanowires), this work further proposed the novel mechanism of the construction of PPy/CS nanoarchitectures with the synergistic effect of CS molecular chains structure and the steric hindrance. Compared to the undoped PPy, MC3T3-E1 cells with PPy/CS nanoarchitectures possessed stronger proliferation and osteogenic differentiation capability. This suggests that PPy/CS nanoarchitectures have appropriate biocompatibility. Altogether, the nanoarchitectured PPy/CS may find application in the regeneration of bone defect.
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