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  • Title: Ligand-controlled regiodivergent palladium-catalyzed decarboxylative allylation reaction to access α,α-difluoroketones.
    Author: Yang MH, Orsi DL, Altman RA.
    Journal: Angew Chem Int Ed Engl; 2015 Feb 16; 54(8):2361-5. PubMed ID: 25581845.
    Abstract:
    α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. To access the α-allyl-α,α-difluoroketone substructure, complementary palladium-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the fluorination pattern of the substrate enabled the ligands to dictate the regioselectivity of the transformations.
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