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  • Title: Autoradiographic distribution of 125I-VIP binding in the rat adrenal cortex.
    Author: Cunningham LA, Holzwarth MA.
    Journal: Peptides; 1989; 10(5):1105-8. PubMed ID: 2558364.
    Abstract:
    Using in vitro autoradiography, 125I-VIP binding was found to be concentrated in the capsule and glomerulosa of the rat adrenal cortex. The densest receptor distribution was coincident with the distribution of VIP nerve fibers that arborize extensively in the capsule and glomerulosa. The specificity of this binding was demonstrated using unlabelled VIP, ACTH and angiotensin II. The presence and distribution of 125I-VIP binding sites provides the link between the previously found VIP nerves and the steroidogenic effect of exogenous VIP, thereby substantiating the physiological role of VIP-containing autonomic nerves in the regulation of adrenocortical cell function.
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