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  • Title: Anthelmintic drug discovery: into the future.
    Author: Geary TG, Sakanari JA, Caffrey CR.
    Journal: J Parasitol; 2015 Apr; 101(2):125-33. PubMed ID: 25584662.
    Abstract:
    The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.
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