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  • Title: Synthesis of isoindolinones via a ruthenium-catalyzed cyclization of N-substituted benzamides with allylic alcohols.
    Author: Manoharan R, Jeganmohan M.
    Journal: Chem Commun (Camb); 2015 Feb 18; 51(14):2929-32. PubMed ID: 25587828.
    Abstract:
    N-Substituted aromatic and heteroaromatic amides reacted with substituted allylic alcohols in the presence of a ruthenium catalyst, AgSbF6 and a Cu(OAc)2·H2O oxidant, affording 3-substituted isoindolinone derivatives with diverse substituents in good to excellent yields. A possible reaction mechanism involving a five-membered ruthenacycle intermediate was proposed and strongly supported by experimental evidence.
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