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  • Title: Insulin does not activate a phosphoinositide-specific phospholipase C in adipocytes.
    Author: Etindi R, Fain JN.
    Journal: Mol Cell Endocrinol; 1989 Dec; 67(2-3):149-53. PubMed ID: 2558935.
    Abstract:
    Phosphoinositide-specific phospholipase C (PI-PLC) activity was determined in homogenates of adipocytes treated with maximal concentrations of insulin. PI-PLC activity measured using exogenous [3H]phosphatidylinositol [( 3H]PI) and exogenous [3H]phosphatidylinositol 4,5-bisphosphate [( 3H]PIP2) was not altered by prior exposure of adipocytes to insulin. It was possible to see oxytocin-induced breakdown of phosphoinositides but no effect of insulin was seen in intact adipocytes.
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