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  • Title: Hyperprolactinemia in hepatic encephalopathy may result from impaired central dopaminergic neurotransmission.
    Author: Corenblum B, Shaffer EA.
    Journal: Horm Metab Res; 1989 Dec; 21(12):675-7. PubMed ID: 2559014.
    Abstract:
    Ten patients with liver disease and hepatic encephalopathy (HE) and eight normal controls were studied. Five of the 10 HE patients had hyperprolactinemia. The administration of L-dopa produced a decrease of serum prolactin in all. Prior administration of Carbidopa, a peripheral decarboxylase inhibitor, did not change the prolactin suppression by L-dopa in the normal controls or in the patients with normal baseline prolactin levels. In the hyperprolactinemic group, Carbidopa significantly inhibited the response to L-dopa. Impaired central neurotransmission, at least involving the hypothalamic-pituitary dopaminergic system, may underlie the hyperprolactinemia in HE.
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