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  • Title: Thrombin-antithrombin III complexes in the prediction of deep vein thrombosis following total hip replacement.
    Author: Hoek JA, Nurmohamed MT, ten Cate JW, Büller HR, Knipscheer HC, Hamelynck KJ, Marti RK, Sturk A.
    Journal: Thromb Haemost; 1989 Dec 29; 62(4):1050-2. PubMed ID: 2559485.
    Abstract:
    In 196 consecutive patients who underwent elective total hip surgery we investigated the diagnostic accuracy of the thrombin-antithrombin III complex immunoassay, as assessed on the first, fourth and tenth postoperative day, for the development of deep vein thrombosis (DVT). Patients received either LMW-heparinoid (n = 97) or placebo (n = 99) and underwent contrast venography on the tenth postoperative day. Thrombin-antithrombin III (T-AT) plasma levels were raised in all patients on the first postoperative day and gradually decreased during the study period. T-AT plasma levels were significantly higher in patients developing DVT when compared to patients without DVT and remained so until day 10. This difference was apparent both in the LMW-heparinoid group as well as in the placebo-treated patients. ROC-curve analysis revealed no satisfactory discriminative power for the diagnosis of developing DVT at any of the studied cut-off values for T-AT. We conclude that the postoperative determination of T-AT complex plasma concentrations in hip surgery patients has no clinical utility in the prediction of postoperative DVT.
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