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  • Title: HIV1 and HIV2: two ancient viruses for a new disease?
    Author: Le Guenno B.
    Journal: Trans R Soc Trop Med Hyg; 1989; 83(6):847. PubMed ID: 2559513.
    Abstract:
    The availability of serum specimens collected in 1965 in a rural region of the Ivory Coast for a serosurvey of infection with rickets and arbovirus led to the findings that human immunodeficiency viruses (HIV) 1 and 2 have a long history. The sera were screened for antibodies to HIV 1 and 2 through enzyme-linked immunosorbent assays, and positive findings were confirmed by Western blot. Of the 349 sera analyzed, 9 were positive only for HIV 1, 3 were positive only for HIV 2, and 15 were positive for both HIV 1 and 2. When Western blot analysis was performed, 13 sera recognized only some gag-coded proteins (especially P25 and 55) on HIV 1 blots without any reaction to HIV 2 antibodies. 2 contained antibodies against env-, gag-, and pol-coded proteins; 1 on an HIV 2 blot form 1965 and 1 on both viruses in the 1969 batch. These findings indicate that 2 people were infected with HIV 2 during the 1960s and 13 (3.7%) had antibodies against an infectious agent that shared epitopes with HIV 1 gag-coded proteins but not HIV 2.
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