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  • Title: Acetylator phenotype and short-course chemotherapy for tuberculosis in Papua New Guinea.
    Author: Currie B, Krause V, Mondia P, Hudson B.
    Journal: P N G Med J; 1989 Dec; 32(4):259-62. PubMed ID: 2560598.
    Abstract:
    In Papua New Guinea the slow acetylator phenotype is unusual and peripheral neuropathy during isoniazid therapy is uncommon. Acetylator status and other factors influencing isoniazid-induced peripheral neuropathy are discussed, and statistics from Papua New Guinea are presented. The relevance of acetylator phenotype to other side-effects of isoniazid is less well defined. Prophylactic pyridoxine supplementation during short-course chemotherapy for tuberculosis is not generally necessary in the daily 'A' regimen, but should be maintained in the twice-weekly (high-dose isoniazid) 'B' regimen for adults and children over 20 kg.
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