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  • Title: NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release.
    Author: Hu Z, Vashlishan-Murray AB, Kaplan JM.
    Journal: J Neurosci; 2015 Jan 21; 35(3):1038-42. PubMed ID: 25609620.
    Abstract:
    A neuropeptide (NLP-12) and its receptor (CKR-2) potentiate tonic and evoked ACh release at Caenorhabditis elegans neuromuscular junctions. Increased evoked release is mediated by a presynaptic pathway (egl-30 Gαq and egl-8 PLCβ) that produces DAG, and by DAG binding to short and long UNC-13 proteins. Potentiation of tonic ACh release persists in mutants deficient for egl-30 Gαq and egl-8 PLCβ and requires DAG binding to UNC-13L (but not UNC-13S). Thus, NLP-12 adjusts tonic and evoked release by distinct mechanisms.
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