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  • Title: [Regulation of the postsynaptic alpha-1-adrenoreceptors of the smooth muscle of the nictitating membrane in the cat].
    Author: Telina EN, Kirshin SV, Nizamov RS, Akhmedzianov RKh, Khamitov KhS.
    Journal: Neirofiziologiia; 1989; 21(6):735-41. PubMed ID: 2561006.
    Abstract:
    Radioassay binding of the smooth muscle of the nictitating membrane of cat has revealed the specific binding sites of [3H]prazosin corresponding to alpha-1 adrenoceptors. There was a significant increase in the number of alpha-1 adrenoceptors without any changes in their affinity. Incubation of the culture of the preliminary sympathectomized smooth muscle with noradrenaline decreased the number of alpha-1 adrenoceptors also without altering the affinity of binding. So, it is concluded that sympathetic nervous system regulated the number of postsynaptic alpha-1 adrenoceptors by means of neurotransmitter (noradrenaline).
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