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  • Title: [The effect of cobalt on the dynamics of membrane-bound calcium in the cerebral cortex structures].
    Author: Samoĭlov MO, Semenov DG, Cherniatchik GIu.
    Journal: Biofizika; 1989; 34(6):1024-7. PubMed ID: 2561080.
    Abstract:
    Cobalt (Co2+) influence on calcium bound (Cab2+) dynamics detected by a fluorescent chlorotetracyclin probe (CTC), as well as bioelectric activity were studied in the feline vital brain cortex preparation with contact microscopy and microelectrode technique. It has been found that Co2+ applied on the preparation surface or injected ionophoretically into microzones under microscopy produced a distinct decrease of CTC-Cab2+ fluorescence intensity. This indicates a decrease of Cab2+ content in the hydrophobic membrane loci. The effect is reversible and depends on Co2+ concentration. Neuronal excitation appeared after the fluorescence decrease up to 5-12% to the start level. It has been concluded that Cab2+ content dynamics plays an important role in the Co2+ "seizure" discharges mechanisms in the cortex.
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