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  • Title: General and mild Ni(0)-catalyzed α-arylation of ketones using aryl chlorides.
    Author: Fernández-Salas JA, Marelli E, Cordes DB, Slawin AM, Nolan SP.
    Journal: Chemistry; 2015 Mar 02; 21(10):3906-9. PubMed ID: 25611197.
    Abstract:
    A general methodology for the α-arylation of ketones using a nickel catalyst has been developed. The new well-defined [Ni(IPr*)(cin)Cl] (1 c) pre-catalyst showed great efficiency for this transformation, allowing the coupling of a wide range of ketones, including acetophenone derivatives, with various functionalised aryl chlorides. This cinnamyl-based Ni-N-heterocyclic carbene (NHC) complex has demonstrated a different behaviour to previously reported NHC-Ni catalysts. Preliminary mechanistic studies suggest a Ni(0)/Ni(II) catalytic cycle to be at play.
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