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  • Title: Interrelationship between cyclic AMP level and chondrogenesis in vitro.
    Author: Hadházy C, László MB.
    Journal: Arch Ital Anat Embriol; 1989; 94(3):263-6. PubMed ID: 2561389.
    Abstract:
    A consistent chondrogenesis takes place in micro-mass cultures of stage 23-24 chicken limb bud mesenchymal cells. In these cultures a short, marked elevation of cAMP level was detected at the time of the onset of cartilage phenotype expression. On the other hand, exogeneous glycosaminoglycans which inhibited chondrogenesis caused a reduction in the cAMP level of the cells. These correlations between cAMP level and phenotypic characteristics suggest that, among other things required in chondrogenesis, cAMP level may be a prominent factor.
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