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  • Title: Action of Ca2+ agonists/antagonists in mammalian peripheral neurons.
    Author: Carbone E, Clementi F, Formenti A, Pollo A, Sher E.
    Journal: Cell Biol Int Rep; 1989 Dec; 13(12):1155-64. PubMed ID: 2561466.
    Abstract:
    The action of several ligands on the low- (LVA,T) and high-threshold (HVA,L and N) Ca channels of adult rat sensory neurons and human neuroblastoma IMR32 cells has been investigated. In both cell types, 40 microM Cd2+ and 6.4 microM /omega-Conotoxin (omega-CgTx) selectively blocked the HVA channels, sparing the majority of LVA channels that were antagonized by amiloride and Ni2+. In 50% of the cells, however, /omega-CgTx spared also a 15% of HVA channels that proved to be sensitive to BAY K 8644. The agonistic action of BAY K 8644 on [omega-CgTx-resistant HVA channels caused a large Ba current increase, prolonged current deactivation and acceleration of HVA channels inactivation that was particularly evident in adult rat DRG.
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