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  • Title: Palmolein and olive oil consumed within a high protein test meal have similar effects on postprandial endothelial function in overweight and obese men: A randomized controlled trial.
    Author: Stonehouse W, Brinkworth GD, Noakes M.
    Journal: Atherosclerosis; 2015 Mar; 239(1):178-85. PubMed ID: 25617858.
    Abstract:
    OBJECTIVE: This study assessed the postprandial effects of high fat, high protein meals containing either palmolein or olive oil on endothelial function in overweight/obese men. DESIGN: 28 men (32-65 yr; 25-35 kg/m(2)) consumed, in random order 1 wk apart, isocaloric high protein, high fat meals (2791 kJ, 40 g protein (∼3 g l-arginine), 44 g fat, 21 g carbohydrate) prepared with either 40 g palmolein or 40 g olive oil after an overnight fast. The SFA:MUFA:PUFA ratio of the oils were: palmolein, 42:47:12; olive oil, 17:76:7. Brachial artery flow-mediated dilatation (FMD), circulating endothelial function markers, nitrotyrosine (oxidative stress marker), triglycerides, glucose and insulin were assessed pre-meal and hourly for 5 h. Mixed model procedures were used to analyze the data. RESULTS: Meal consumption increased serum triglycerides (time effect, P < 0.001); with no meal differences (meal × time interaction, P = 0.93). Serum insulin peaked 1 h post-consumption and returned to pre-meal concentrations by 5 h with both meals (time effect, P < 0.001; meal × time effect, P = 0.68). FMD, serum intercellular adhesion molecule-1 (ICAM-1) and E-selectin did not change (meal × time effect, P > 0.4). Olive oil transiently increased plasma nitrotyrosine after 1 h compared to palmolein (meal × time interaction, P = 0.002) whereas both meals increased serum vascular cell adhesion molecule-1 (VCAM-1) after 1 h (time effect, P < 0.001; meal × time interaction, P = 0.98). Both nitrotyrosine and VCAM-1 returned to pre-meal concentrations after 2 h. CONCLUSION: In the context of a high protein meal, palmolein similarly to olive oil did not affect postprandial endothelial function in overweight/obese men. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ANZCTR) (http://www.anzctr.org.au/default.aspx). Trial ID: ACTRN12613000136707.
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