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  • Title: VIP-helodermin receptors in the murine virus-induced T lymphoma cell line BL/VL3 recover less rapidly than beta-adrenoceptors after down regulation.
    Author: Damien C, Robberecht P, Abello J, Hooghe R, Christophe J.
    Journal: J Recept Res; ; 9(6):441-9. PubMed ID: 2561794.
    Abstract:
    The time course of recovery of beta-adrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of beta-adrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: beta-adrenoceptors recovered faster than VIP/helodermin receptors.
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