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  • Title: [Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].
    Author: Modesti A, D'Orazi G, Scarpa S, Mezi S, Gatti F, Aloise G, Gerace D, Guglielmi P, Simonelli L, Modesti M.
    Journal: G Chir; 1989 May; 10(5):245-9. PubMed ID: 2562045.
    Abstract:
    Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.
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