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  • Title: Effects of food intake on pharmacokinetics of mosapride in beagle dogs.
    Author: Chae JW, Song BJ, Baek IH, Yun HY, Ma JY, Kwon KI.
    Journal: J Vet Pharmacol Ther; 2015 Oct; 38(5):497-9. PubMed ID: 25622855.
    Abstract:
    This study was performed to determine the pharmacokinetic profile of mosapride in fasting and fed states. A single 5-mg oral dose of mosapride was administered to fasted (n = 15) and fed (n = 12) beagle dogs, and the plasma concentrations of mosapride were measured by liquid chromatography-tandem mass spectrometry. The resultant data were analyzed by noncompartmental analysis (NCA). Mosapride was absorbed in fasted and fed dogs with similar Tmax . Both Cmax and AUC were significantly higher in the fasting group than in fed dogs, being four times (10.51 μg/mL vs. 2.76 μg/mL) and 3.5 times higher (38.53 h · μg/mL vs. 10.22 h · μg/mL), respectively. These findings suggest that food intake affects the pharmacokinetics of mosapride and that the dosage regimen for this drug need to be reconsidered.
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