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  • Title: PAF receptor. 2. Quantitative hydrophobic contribution of the agonist's etheroxid chain.
    Author: Heymans F, Steiner E, Jouquey S, Godfroid JJ.
    Journal: J Lipid Mediat; 1989; 1(5):303-12. PubMed ID: 2562436.
    Abstract:
    In order to undertake a quantitative assessment of the contribution of the hydrophobic effect of the etheroxid chain to agonistic activity, it was necessary to include in the calculated data a highly lipophilic platelet-activating factor (PAF) analogue. The synthesis of such a compound--racemic 1-O-docosyl-2-O-acetylglycero-3-phosphocholine (C22 PAF)--is described. The regression analysis performed with data of 14 etheroxid analogues (reviewed by Godfroid et al., 1987), combined with data obtained with C22 PAF, is significant with respect to a parabolic evolution between lipophilicity of the chain and the logarithm of relative platelet stimulation. This result is characteristic of a hydrophobic interaction between the agonist and the PAF receptor.
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