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  • Title: Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols.
    Author: Zhao ZL, Xu QL, Gu Q, Wu XY, You SL.
    Journal: Org Biomol Chem; 2015 Mar 14; 13(10):3086-92. PubMed ID: 25625805.
    Abstract:
    Palladium-catalyzed asymmetric intramolecular Friedel-Crafts type allylic alkylation reaction of phenols was developed under mild conditions. In the presence of Pd2(dba)3 with (1R,2R)-DACH-phenyl Trost ligand (L2) in toluene at 50 °C, the reaction provides various C4 substituted tetrahydroisoquinolines with moderate to excellent yields, regioselectivity and enantioselectivity.
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