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  • Title: Enantioselective palladium-catalyzed dearomative cyclization for the efficient synthesis of terpenes and steroids.
    Author: Du K, Guo P, Chen Y, Cao Z, Wang Z, Tang W.
    Journal: Angew Chem Int Ed Engl; 2015 Mar 02; 54(10):3033-7. PubMed ID: 25631391.
    Abstract:
    A novel enantioselective palladium-catalyzed dearomative cyclization has been developed for the efficient construction of a series of chiral phenanthrenone derivatives bearing an all-carbon quaternary center. The effectiveness of this method in the synthesis of terpenes and steroids was demonstrated by a highly efficient synthesis of a kaurene intermediate, the facile construction of the skeleton of the anabolic steroid boldenone, and the enantioselective total synthesis of the antimicrobial diterpene natural product (-)-totaradiol.
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