These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Neuroleptic augmentation with alprazolam: clinical effects and pharmacokinetic correlates.
    Author: Douyon R, Angrist B, Peselow E, Cooper T, Rotrosen J.
    Journal: Am J Psychiatry; 1989 Feb; 146(2):231-4. PubMed ID: 2563211.
    Abstract:
    Alprazolam added to stable doses of neuroleptics in nine schizophrenic patients was associated with a 20%-30% mean reduction in positive and negative symptoms, although clinical response was variable and in some patients particularly brisk. The authors examined the possibilities of a pharmacokinetic effect of alprazolam on neuroleptic plasma levels and of a clinical effect of alprazolam. The modest increase in mean neuroleptic plasma levels did not correlate with clinical change, but those patients with the highest alprazolam plasma levels tended to show more robust clinical responses.
    [Abstract] [Full Text] [Related] [New Search]